Histopathology Atlas

LIVER AND BILE DUCTS

• Histology:

  • Liver

• Non-neoplastic lesions:

  • Centrilobular necrosis

  • Steatosis

  • Cirrhosis

  • Cholestasis of liver

  • Nutmeg liver

  • Fulminant hepatitis

• Benign neoplasms:

  • Cavernous hemangioma

  • Hepatic adenoma

  • Focal nodular hyperplasia

  • Angiomyolipoma

  • Inflammatory myofibroblastic tumor

• Malignant neoplasms:

  • Hepatocellular carcinoma

  • Cholangiocarcinoma

  • Hepatoblastoma

• Metastases:

  • Metastatic adenocarcinoma

  • Metastatic melanoma

  • Metastatic small cell carcinoma

  • Metastatic neuroblastoma

ESOPHAGUS

• Histology:

  • Esophagus

• Esophagitis:

  • Candida esophagitis

  • Acute esophagitis

  • Reflux esophagitis

• Non-neoplastic lesions:

  • Esophageal varices

• Premalignant:

  • Barrett's esophagus without dysplasia

  • Barrett's esophagus with low grade dysplasia

• Malignant neoplasms:

  • Adenocarcinoma

  • Squamous cell carcinoma

STOMACH

• Histology:

  • Corpus

  • Antrum

• Gastritis:

  • Helicobacter gastritis

  • Chronic atrophic gastritis with intestinal metaplasia

  • High grade intraepithelial neoplasia - dysplasia

• Gastric polyps:

  • Hyperplastic polyp

  • Fundic gland polyp

  • Gastric adenoma

• Malignant neoplasms:

  • Adenocarcinoma, intestinal type

  • Adenocarcinoma, diffuse type - signet ring cell carcinoma

  • MALT lymphoma

  • Malignant melanoma

• Mesenchymal tumors:

  • GIST, gastrointestinal stromal tumor

SMALL INTESTINE

• Histology:

  • Duodenum

  • Jejunum

• Malabsorption:

  • Celiac sprue

• Inflammatory disorders:

  • Crohn disease

  • Peritonitis

• Benign lesions/neoplasms:

  • Ectopic gastric mucosa

  • Heterotopic pancreas

• Mesenchymal tumors:

  • GIST, gastrointestinal stromal tumor

LARGE INTESTINE

• Histology:

  • Large intestine

• Inflammatory disorders:

  • Pseudomembranous colitis

  • Crohn's disease

  • Chronic ulcerative colitis

• Polyps:

  • Peutz-Jeghers polyp

  • Juvenile polyp

  • Villous adenoma

  • Tubulovillous adenoma

  • Tubular adenoma

  • Hyperplastic polyp

  • Traditional serrated adenoma

• Non-neoplastic disorders

• Amyloidosis

• Malignant neoplasms:

  • Adenocarcinoma

  • Malignant melanoma

  • Medullary carcinoma

  • Leiomyosarcoma

  • Mixed adenoneuroendocrine carcinoma (MANEC)

• Mesenchymal tumors:

  • GIST, gastrointestinal stromal tumor

  • Cavernous lymphangioma

  • Solitary fibrous tumor

APPENDIX

• Histology:

  • Appendix

• Appendicitis:

  • Gangrenous appendicitis

  • Phlegmonous appendicitis

  • Chronic appendicitis

  • Oxyuriasis

• Neoplasms:

  • Mucinous cystadenoma

  • Pseudomyxoma peritonei

  • Adenocarcinoma

  • Carcinoid - well differnetiated neuroendocrine tumor/neoplasm (NET)